1. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This really is an impurity relevant to bortezomib, a proteasome inhibitor Utilized in the treatment method of a number of myeloma. Its synthesis or review is vital for ensuring the purity and basic safety on the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-7): A precursor within the synthesis of abiraterone acetate, a drug Employed in the cure of prostate cancer by inhibiting androgen output.
Imatinib Intermediate (CAS NO. 152460-10-one): A crucial compound during the synthesis of imatinib, a drug that targets distinct forms of cancer, which include Continual myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Employed in the synthesis of docetaxel, a chemotherapy medication that treats numerous cancers such as breast, lung, and prostate most cancers.
two. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, 8): These are intermediates while in the synthesis of gemcitabine, an anti-most cancers drug. Their study is crucial for optimizing the manufacturing system and ensuring substantial purity.
Lapatinib Intermediate (CAS NO. 231278-eighty four-five): Lapatinib is employed to deal with breast most cancers, and these intermediates are involved in its creation.
Fulvestrant Intermediates: Fulvestrant can be an estrogen receptor antagonist used in the treatment Abiraterone of breast most cancers. Many intermediates assist in the synthesis of this drug.
Paclitaxel Side Chain Acid (CAS NO. 949023-sixteen-9): This intermediate is used in the synthesis of paclitaxel, a chemotherapy drug successful in dealing with cancers such as ovarian, breast, and lung cancer.
3. Other Notable Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-three): A chemotherapy drug Utilized in the remedy of colorectal cancer and compact mobile lung cancer.
three-Amino-1-hydroxyadamantane (CAS 702-eighty two-9): This compound is involved in the synthesis of adamantane derivatives, that have different applications, including antiviral Attributes.
Vildagliptin Intermediates: CAS NO. 155405-80-4 Utilized in the creation of vildagliptin, an oral drug for form 2 diabetic issues that inhibits the enzyme DPP-4 to control blood sugar amounts.
four. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-48-one): This compound is associated with the synthesis of assorted gluconic acid derivatives, which might be used in food stuff, pharmaceutical, and industrial programs.
Canagliflozin Intermediate two: A precursor inside the synthesis of canagliflozin, a medication made use of to control type 2 diabetic issues by inhibiting sodium-glucose co-transporter 2 (SGLT2).